How do enzymes distinguish them from chemical catalysts? 2
Why are coenzymes often used as dietary supplements? 2
What is the role of the active site in enzyme catalysis, and how does it facilitate substrate binding? 4
How do enzymes lower activation energy without altering the free energy change of a reaction? 4
‘Enzymes are highly substrate and reaction specific catalysts.’ - Justify the statement 4
Describe the factors affecting the enzyme activity. 5
Explain the interplay between enzyme inhibitors and coenzymes in the design of chemotherapy drugs. 3
Discuss the impact of enzyme and coenzyme deficiencies on metabolic diseases, and suggest possible therapeutic interventions. 4
Define the term ‘turnover number’ and explain its importance in enzymatic reactions. 4
Why are coenzymes essential for enzyme function, and how do they contribute to catalysis? 4
Session: 2020 - 2021
Why are enzymes protein in nature? 2
What does feedback enzyme inhibition mean? 2
Differentiate between proenzyme and coenzyme. 2
“Vitamins are often precursor to coenzymes.” - Justify the statement 2
“The active sites of enzymes possess some common features.” - Justify the statement 4
How do enzymes accelerate a chemical reaction? 4
‘Enzymes are highly substrate and reaction specific catalysts.’ - Justify the statement 4
Describe the factors affecting enzyme activity. 4
‘Enzyme inhibitors are used as therapeutic agents.’ - Justify with examples. 4
How can enzymes be used in the treatment of disease? Explain with an example. 4
Describe the mechanisms of enzyme regulation. 4
Why are the proteins called the workhorses of the cell? 4
Why induced fit model is the best model for the description of an active site? 4
Session: 2019 - 2020
Why are enzymes heat sensitive in nature? 2
What does feedback enzyme inhibition mean? 2
‘Vitamins are often precursor to coenzymes.’ - Justify the statement 2
Discuss the induced-fit model for an enzyme reaction. 4
Briefly describe the different types of enzyme inhibition. 4
Write the therapeutic benefit of enzyme inhibition. 4
How do enzyme concentration and hydrogen ion concentration affect enzyme activity? 4
‘Competitive inhibitors can be used as therapeutic agents.’ - Justify with examples. 4
How can enzymes be used in the treatment of disease? Explain with example. 4
What are the significances of Lineweaver-Burk double reciprocal plot? 4
Describe the mechanisms of enzyme regulation. 4
‘Why are allosteric modifiers rarely used as drugs?’ 4
Why induced fit model is the best model for the description of an active site? 4
How do cofactors and coenzymes vary? 4